Remdesivir GS-5734 CAS 1809249-37-3 COVID-19 API High Quality

Short Description:

Chemical Name: Remdesivir (GS-5734)

CAS: 1809249-37-3

Appearance: White to Off-White Solid Powder

Assay: 98.0%~102.0%

Remdesivir for the treatment of COVID-19

API High Quality, Commercial Production

Inquiry: alvin@ruifuchem.com


Product Detail

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Description:

Chemical Properties:

Chemical Name Remdesivir 
Synonyms GS-5734; 2-ethylbutyl ((S)-(((2R,3S,4R,5R)-5-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
CAS Number 1809249-37-3
CAT Number RF-API96
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C27H35N6O8P
Molecular Weight 602.58
Density 1.47±0.1 g/cm3
Brand Ruifu Chemical

Specifications:

Item Specifications
Appearance White to Off-White Solid Powder
Identification A IR: The infrared absorption spectrum of the product should be consistent with that of the reference substance
Identification B HPLC Retention time similar to reference substance
Specific Rotation -19.0° ~ -22.0°
Solubility Solunle in Methanol, Sparingly Soluble in Ethanol, Slightly Soluble in Acetonitrile, Practically Insoluble in Water
Related Substances
Any Individual Impurity ≤0.10%
Total Impurities ≤1.0%
RD-3.1 ≤0.10%
RD-C ≤0.10%
RD-D ≤0.10%
RD-E ≤0.10%
RP-Isomer ≤0.10%
Nitrophenol ≤0.10%
Residual Solvents
Methanol Dichloride ≤6000ppm
Acetone ≤5000ppm
Isopropyl Alcohol ≤5000ppm
Acetonitrile ≤410ppm
Dichloromethane ≤600ppm
Methyl tert Butyl Ether ≤5000ppm
Ethyl Acetate ≤5000ppm
Tetrahydrofuran ≤720ppm
n-Heptane ≤5000ppm
Assay 98.0%~102.0% (Calculated on the dried basis)
Total Aerobic Counts
Aerobic Bacteria ≤100cfu/g
Yeast and Mould ≤10cfu/g
E. Coil Negative
Bacterial Endotoxin ≤1.0EU
Heavy Metals ≤20ppm
Test Standard Enterprise Standard
Usage API, COVID-19

Package & Storage:

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer's requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Advantages:

1

FAQ:

Application:

Remdesivir (CAS 1809249-37-3), sold under the brand name Veklury, is a broad-spectrum antiviral medication developed by the biopharmaceutical company Gilead Sciences. It is administered via injection into a vein. During the COVID-19 pandemic, remdesivir was approved or authorized for emergency use to treat COVID-19 in around 50 countries. Updated guidelines from the World Health Organization in November 2020 include a conditional recommendation against the use of Remdesivir for the treatment of COVID-19. Remdesivir was originally developed to treat hepatitis C, and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID-19. The most common side effect in healthy volunteers is raised blood levels of liver enzymes (a sign of liver problems). The most common side effect in people with COVID-19 is nausea. Side effects may include liver inflammation and an infusion-related reaction with nausea, low blood pressure, and sweating. Remdesivir is a prodrug that is intended to allow intracellular delivery of GS-441524 monophosphate and subsequent biotransformation into GS-441524 triphosphate, a ribonucleotide analogue inhibitor of viral RNA polymerase. 

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